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INFLUENCE OF IFENPRODIL ON THE ACTH-INDUCED BEHAVIORAL SYNDROME IN RATS

被引：4
作者：
GENEDANI, S
BERNARDI, M
BERTOLINI, A
机构：
[1] Institute of Pharmacology, University of Modena, I41100 Modena
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 01期
关键词：
IFENPRODIL; POLYAMINE; ACTH (ADRENOCORTICOTROPIN); BEHAVIOR; NMDA RECEPTOR; (RAT);
D O I：
10.1016/0014-2999(94)90577-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ifenprodil - an antagonist at the modulatory site of the NMDA receptor complex sensitive to polyamines - intraperitoneally injected at doses of 3 or 10 mg/kg, dose dependently prevented the behavioral syndrome induced by intracerebroventricular administration of adrenocorticotropin (ACTH)-(1-24) in adult male rats (excessive grooming, stretching, yawning, penile erections). These data further support a role of the brain ornithine decarboxylase (ODC)-polyamine system in the ACTH-induced behavioral syndrome, and may suggest an involvement of excitatory amino acids.
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页码：77 / 80
页数：4
相关论文
共 31 条
[1]   PHARMACOLOGICAL ACTIONS OF IFENPRODIL IN THE RAT ISOLATED ANOCOCCYGEUS MUSCLE [J].
ADEAGBO, ASO ;
MAGBAGBEOLA, AO .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (11) :833-835
[2]   POLYAMINE-SENSITIVE BINDING OF [I-125] IFENPRODIL IN WASHED, FROZEN-THAWED SYNAPTIC-MEMBRANES - EVIDENCE FOR HIGH-AFFINITY BINDING REQUIRING AN OPEN NMDA CHANNEL [J].
BEART, PM ;
MERCER, LD ;
CONWAY, EL ;
SEARLE, AJ .
NEUROSCIENCE LETTERS, 1992, 142 (02) :219-222
[3]  
BENAVIDES J, 1992, J PHARMACOL EXP THER, V260, P896
[4]   INDUCTION OF SEXUAL EXCITEMENT BY ACTION OF ADRENOCORTICOTROPHIC HORMONE IN BRAIN [J].
BERTOLINI, A ;
VERGONI, W ;
GESSA, GL ;
FERRARI, W .
NATURE, 1969, 221 (5181) :667-+
[5]   BEHAVIORAL-EFFECTS OF ACTH AND MSH PEPTIDES [J].
BERTOLINI, A ;
GESSA, GL .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1981, 4 (02) :241-251
[6]   IFENPRODIL AND SL-82.0715 ARE ANTAGONISTS AT THE POLYAMINE SITE OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR [J].
CARTER, C ;
RIVY, JP ;
SCATTON, B .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 164 (03) :611-612
[7]  
CARTER C, 1988, J PHARMACOL EXP THER, V247, P1222
[8]  
CARTER C, 1991, EXCITATORY AMINO ACI, P136
[9]  
CARTER CJ, 1990, J PHARMACOL EXP THER, V253, P475
[10]   PHARMACOLOGICAL CHARACTERIZATION AND AUTORADIOGRAPHIC DISTRIBUTION OF POLYAMINE-SENSITIVE [H-3] IFENPRODIL BINDING-SITES IN THE RAT-BRAIN [J].
DANA, C ;
BENAVIDES, J ;
SCHOEMAKER, H ;
SCATTON, B .
NEUROSCIENCE LETTERS, 1991, 125 (01) :45-48
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