NONLINEAR DIFFUSION OF A GROWTH-INHIBITORY FACTOR IN MULTICELL SPHEROIDS

被引：29

作者：

CHAPLAIN, MAJ ^{[1
]}

BENSON, DL ^{[1
]}

MAINI, PK ^{[1
]}

机构：

[1] UNIV OXFORD,INST MATH,CTR MATH BIOL,OXFORD,ENGLAND

来源：

MATHEMATICAL BIOSCIENCES | 1994年 / 121卷 / 01期

关键词：

D O I：

10.1016/0025-5564(94)90029-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A mathematical model is presented for the production of a growth inhibitory factor (GIF) within a multicell spheroid. The model is based on the assumption that the GIF diffuses within the spheroid in a nonlinear spatially dependent manner. This is in contrast with previous models, in which the nonlinearity was assumed in the production term. The results of the new model are compared with those of previous models and with experimental data.

引用

页码：1 / 13

页数：13

共 44 条

[1] ANALYSIS OF CELLULAR INTERACTIONS IN DENSITY-DEPENDENT INHIBITION OF 3T3-CELL PROLIFERATION [J].