SUBCHRONIC TOXICITY OF FUMONISIN B-1 TO MALE AND FEMALE RATS

被引：16

作者：

VOSS, KA

CHAMBERLAIN, WJ

BACON, CW

RILEY, RT

NORRED, WP

机构：

[1] Toxicology and Mycotoxin Research Unit, Agricultural Research Service, United States Department of Agriculture, Richard B. Russell Agricultural Research Center, Athens, GA, 30604-5677

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1995年 / 12卷 / 03期

关键词：

FUMONISINS; HEPATOXICITY; NEPHROTOXICITY; SPHINGOLIPIDS;

D O I：

10.1080/02652039509374332

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fumonisins are a class of mycotoxins produced by Fusarium moniliforme and other Fusarium spp. These compounds are widely distributed in corn. Equine leukoencephalomalacia, pulmonary oedema in swine, and nephrotoxicity, hepatotoxicity and liver cancer in male rats, all of which are caused by toxic F. moniliforme, have been experimentally reproduced using fumisin B-1 (FB1) (ca 90-94% purity). To investigate the effect of purified (greater than or equal to 99% purity) FB1, to compare the effects of FB1 in males and females, and to obtain dose-response information for FB1, three rats per sex were fed diets containing 0, 15, 50 or 150 FB1 for 4 weeks. Serum chemical, organ weight and histopathological evidence showed that 150 mg/kg FB1 was hepatotoxic in both sexes. Nephrosis was found in males fed greater than or equal to 15 mg/kg and females fed greater than or equal to 50 mg/kg FB1. Altered sphingolipid profiles, specifically increased free sphinganine concentrations and increased sphinganine: sphingosine ratios, were found in the liver, kidney, serum and urine of FB1-fed rats. These findings support the hypothesis that in vivo toxicity caused by fumonisins may result from altered sphingolipid metabolism.

引用

页码：473 / 478

页数：6

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