THE RADIATION-CHEMISTRY OF D(CPGPTPA) IN THE PRESENCE OF OXYGEN

被引：30

作者：

BUDZINSKI, EE

DAWIDZIK, JD

WALLACE, JC

FREUND, HG

BOX, HC

机构：

[1] Biophysics Department, Roswell Park Cancer Institute, Buffalo

来源：

RADIATION RESEARCH | 1995年 / 142卷 / 01期

关键词：

D O I：

10.2307/3578973

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant. (C) 1995 by Radiation Research Society

引用

页码：107 / 109

页数：3

共 7 条

[1] VICINAL LESIONS IN X-IRRADIATED DNA
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