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COLLAGENOLYTIC ACTIVITY IN MIDDLE EAR CHOLESTEATOMA

被引：61
作者：
ABRAMSON, M
机构：
[1] Developmental Biology Laboratory, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass.
来源：
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 1969年 / 78卷 / 01期
关键词：
D O I：
10.1177/000348946907800110
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Middle ear cholesteatoma demonstrated collagenolytic activity when cultured on reconstituted native collagen gels. Lysis of gels occurred when viable epithelium was present. Skin from the bony external auditory meatus and postaural skin also demonstrated collagenolytic activity while skin from the cartilagenous external auditory meatus and upper arm skin showed insignificant activity. A collagenase enzyme was obtained in a cell-free solution and appeared to have a specific site of action on the collagen molecule. © 1969, SAGE Publications. All rights reserved.
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页码：112 / +
页数：1
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