TOTAL SYNTHESIS OF BOTH (+)-COMPACTIN AND (+)-MEVINOLIN - A GENERAL STRATEGY BASED ON THE USE OF A SPECIAL TICL3/C8K MIXTURE FOR DICARBONYL COUPLING

被引：36

作者：

CLIVE, DLJ

MURTHY, KSK

WEE, AGH

PRASAD, JS

DASILVA, GVJ

MAJEWSKI, M

ANDERSON, PC

HAUGEN, RD

HEERZE, LD

机构：

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1988年 / 110卷 / 20期

关键词：

D O I：

10.1021/ja00228a067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：6914 / 6916

页数：3

共 33 条

[1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2]

BALOGH V, 1971, J ORG CHEM, V36, P1339

[3] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM [J].

BROWN, AG ;

SMALE, TC ;

KING, TJ ;

HASENKAMP, R ;

THOMPSON, RH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11) :1165-1173

[4] ON THE MECHANISM OF THE TITANIUM-INDUCED REDUCTIVE COUPLING OF KETONES TO OLEFINS [J].

DAMS, R ;

MALINOWSKI, M ;

WESTDORP, I ;

GEISE, HY .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (02) :248-259

[5]

DAWBER TR, 1980, FRAMINGHAM STUDY

[6] MONACOLIN-K, A NEW HYPOCHOLESTEROLEMIC AGENT THAT SPECIFICALLY INHIBITS 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE [J].

ENDO, A .

JOURNAL OF ANTIBIOTICS, 1980, 33 (03) :334-336

[7] MONACOLIN-K, A NEW HYPOCHOLESTEROLEMIC AGENT PRODUCED BY A MONASCUS SPECIES [J].

ENDO, A .

JOURNAL OF ANTIBIOTICS, 1979, 32 (08) :852-854

[8] ML-236A, ML-236B, AND ML-236C, NEW INHIBITORS OF CHOLESTEROGENESIS PRODUCED BY PENICILLIUM CITRINUM [J].

ENDO, A ;

KURODA, M ;

TSUJITA, Y .

JOURNAL OF ANTIBIOTICS, 1976, 29 (12) :1346-1348

[9] COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE [J].

ENDO, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (04) :401-405

[10] ASYMMETRIC DIELS-ALDER CYCLO-ADDITION REACTIONS WITH CHIRAL ALPHA, BETA-UNSATURATED N-ACYLOXAZOLIDINONES [J].

EVANS, DA ;

CHAPMAN, KT ;

BISAHA, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (04) :1238-1256

← 1 2 3 4 →