SYNTHESIS OF LEU-ABU(P) AND GLU-ABU(P)-LEU - ISOSTERES OF SER(P)-PEPTIDES

被引：28

作者：

TONG, G ^{[1
]}

PERICH, JW ^{[1
]}

JOHNS, RB ^{[1
]}

机构：

[1] UNIV MELBOURNE,DEPT ORGAN CHEM,PARKVILLE,VIC 3052,AUSTRALIA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)97464-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Boc-Asp-Ot-Bu was efficiently converted to Boc-Abu(PO3Me2)-Ot-Bu in five steps then to Boc-Abu(PO3Me2)-OH in two steps. Both the protected amino acids were used in the syntheses of Boc-Leu-Abu(PO3Me2)-Ot-Bu and Boc-Glu(OBzl)-Abu(PO3Me2)-Leu-OBzl by the Boc mode of peptide synthesis. These were deprotected to Leu-Abu(P) and Glu-Abu(P)-Leu by hydrogenolysis followed by bromotimethylsilane treatment. © 1990.

引用

页码：3759 / 3762

页数：4

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