IONTOPHORETIC STUDY OF MEDIAL SEPTAL NEURONS IN THE UNANESTHETIZED RAT

被引：16

作者：

LEE, BH ^{[1
]}

LAMOUR, Y ^{[1
]}

BASSANT, MH ^{[1
]}

机构：

[1] INSERM,UNITE RECH PHYSIOPHARMACOL SYST NERVEUX 161,2 RUE DALESIA,F-75014 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 01期

关键词：

UNANESTHETIZED RAT; MICROIONTOPHORESIS; MEDIAL SEPTAL NEURON; ACETYLCHOLINE; CARBACHOL; URETHANE;

D O I：

10.1016/0304-3940(91)90753-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the iontophoretic applications of glutamate (Glu), gamma-aminobutyric acid (GABA), acetylcholine (ACh) and carbachol (CARB) were studied on neurons located in the medium septal area (MSA) in the unanesthetized rat. In the absence of anesthesia, functional properties of the MSA neurons were significantly different from those observed in the urethane-anesthetized rat (higher variability of discharge rate, lower percentage of rhythmically bursting neurons). Glu excited 80% and GABA inhibited 96% of the MSA neurons. These percentages were similar to those obtained in the urethane-anesthetized rats. In contrast, the percentage of neurons excited by ACh (28%) or by CARB (27.2%) were significantly lower than in the urethane-anesthetized rat. Our results suggest that urethane might alter cholinergic sensitivity in the MSA and confirm that anesthesia can induce a bias in the iontophoretic study of some brain structures.

引用

页码：29 / 32

页数：4

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