SEQUENCE DEPENDENCE IN SOLID-PHASE-SYNTHESIS-CYCLIZATION-CLEAVAGE FOR CYCLO(-ARGINYL-GLYCYL-ASPARTYL-PHENYLGLYCYL-)

被引：55

作者：

NISHINO, N ^{[1
]}

XU, M ^{[1
]}

MIHARA, H ^{[1
]}

FUJIMOTO, T ^{[1
]}

UENO, Y ^{[1
]}

KUMAGAI, H ^{[1
]}

机构：

[1] ASAHI GLASS CO LTD,RES CTR,KANAGAWA KU,YOKOHAMA 221,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 11期

关键词：

PEPTIDE SYNTHESIS; OXIME RESIN; SOLID-PHASE-SYNTHESIS AND CYCLIZATION-CLEAVAGE; CYCLIC TETRAPEPTIDE; ARG-GLY-ASP SEQUENCE;

D O I：

10.1016/S0040-4039(00)91652-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cyclic tetrapeptide with inhibitory activity toward cell adhesion, cyclo(-Arg-Gly-Asp-Phg-) (phg, phenylglycine) (IC50 = 10-mu-M), was synthesized. The cyclization-cleavage of the protected precursor from the oxime resin significantly depended on the sequences of the linear tetrapeptides assembled by solid-phase-synthesis on the resin.

引用

页码：1479 / 1482

页数：4

共 16 条

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