MICE WITH A NULL MUTATION OF THE TGF-ALPHA GENE HAVE ABNORMAL SKIN ARCHITECTURE, WAVY HAIR, AND CURLY WHISKERS AND OFTEN DEVELOP CORNEAL INFLAMMATION

被引:514
作者
MANN, GB
FOWLER, KJ
GABRIEL, A
NICE, EC
WILLIAMS, RL
DUNN, AR
机构
[1] Melbourne Tumour Biology Branch Ludwig Inst. for Cancer Research Post Office Royal Melbourne Hosp. V
关键词
D O I
10.1016/0092-8674(93)90227-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mice homozygous fora disrupted transforming growth factor alpha (TGFalpha) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGFalpha +/- and +/+ animals, TGFalpha -/- mice have a pronounced waviness of the coat. Histological examination of the skin from TGFalpha -/- mice reveals a dramatic derangement of hair follicles. Mice with a disrupted TGFalpha gene also have curly whiskers, first evident on the day of birth. The phenotype of TGFalpha -/- mice is remarkably similar to that of the mouse mutant waved-1 (wa-1). Offspring resulting from crosses between TGFalpha -/- and wa-1 mice display the curly whisker-coat phenotype, indicating that the basis of the wa-1 phenotype is a mutation in the TGFalpha gene. These observations suggest that TGFalpha plays a pivotal role in determining skin architecture and in regulating hair development.
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收藏
页码:249 / 261
页数:13
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