NEURON LOSS AND SHRINKAGE IN THE AMYGDALA IN ALZHEIMERS-DISEASE

被引:60
作者
VEREECKEN, THLG [1 ]
VOGELS, OJM [1 ]
NIEUWENHUYS, R [1 ]
机构
[1] UNIV NIJMEGEN, DEPT ANAT & EMBRYOL, 6500 HB NIJMEGEN, NETHERLANDS
关键词
AMYGDALA; ALZHEIMERS DISEASE; CELL LOSS;
D O I
10.1016/0197-4580(94)90143-0
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Total neuron numbers in the amygdala and in eight of its subnuclei were determined in 9 cases of Alzheimer's disease (AD) and in 6 age-matched controls (AMC). Total neuron numbers were obtained using the fractionator. A neuron loss of 56.3% for the left amygdala and 50.5% for the right amygdala in AD was found, being more severe than previously reported. The subdivisions showed a differential neuron loss ranging from 35.5% in nucleus lateralis of the right amygdala to 70.4% in the nucleus basalis accessorius of the right amygdala. Moreover, a shift in size distribution to smaller neurons could be demonstrated. No left-right hemispheric differences were detected in total neuron numbers in AD and AMC.
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页码:45 / 54
页数:10
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