PRESENCE OF A PROTEIN METHYLESTERASE IN MAMMALIAN-TISSUES

被引：50

作者：

GAGNON, C

机构：

[1] Département de Pharmacologie, Faculté de Médecine Université Laval

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0006-291X(79)91486-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using enzymatically methylated protein-3H methyl esters as substrates, a protein methylesterase activity was observed in mammalian tissues. The product of hydrolysis was identified as radioactive methanol by microdistillation under reduced pressure and formation of a 3,5-dinitrobenzoate derivative. The enzyme was active over a broad range of pH and appeared in all tissues investigated. Since protein carboxyl-methylation is involved in chemotaxis of leukocytes and exocytotic secretion, this protein methylesterase probably participates in the regulation of these processes. © 1979.

引用

页码：847 / 853

页数：7

共 23 条

[1] CHARACTERIZATION AND SUBSTRATE-SPECIFICITY OF A PROTEIN CARBOXYMETHYLASE IN PITUITARY-GLAND [J].