HA1077, A NOVEL CALCIUM ANTAGONISTIC ANTIVASOSPASM DRUG, INCREASES BOTH CEREBRAL BLOOD-FLOW AND GLUCOSE-METABOLISM IN CONSCIOUS RATS

被引：16

作者：

SAKO, K ^{[1
]}

TSUCHIYA, M ^{[1
]}

YONEMASU, Y ^{[1
]}

ASANO, T ^{[1
]}

机构：

[1] ASAHI CHEM IND CO LTD,DEPT PHARMACOL,NOBEOKA 882,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 1-2期

关键词：

CEREBRAL BLOOD FLOW; CEREBRAL GLUCOSE METABOLISM; IODOANTIPYRINE; 2-DEOXYGLUCOSE; HA1077;

D O I：

10.1016/0014-2999(91)90008-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a novel calcium antagonistic antivasospasm drug, HA1077, on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) were studied in 33 anatomically discrete regions of the brain in conscious rats, using the quantitative autoradiographic [C-14]iodoantipyrine and [C-14]2-deoxyglucose techniques. HA1077 was infused i.v. over a 30-min period (1 or 3 mg/kg). HA1077 significantly increased LCBF in 9 of 33 sites in rats given 1 mg/kg, and in 14 of 33 sites in rats given 3 mg/kg compared to the control group given vehicle. Significant increases in LCGU were also noted in 16 of 33 sites in rats given 3 mg/kg. HA1077 increased both cerebral blood flow and glucose metabolism in conscious rats.

引用

页码：39 / 43

页数：5

共 23 条

[1]

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[2]

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