GLIA MATURATION FACTOR-BETA STIMULATES AXON REGENERATION IN TRANSECTED RAT SCIATIC-NERVE

被引：16

作者：

HARMAN, K

KATNICK, J

LIM, R

ZAHEER, A

DELATORRE, JC

机构：

[1] UNIV OTTAWA,DIV NEUROSURG,OTTAWA K1H 8M5,ONTARIO,CANADA

[2] UNIV IOWA,DEPT NEUROL,DIV NEUROCHEM & NEUROBIOL,IOWA CITY,IA 52242

来源：

BRAIN RESEARCH | 1991年 / 564卷 / 02期

关键词：

SCIATIC NERVE; TRANSECTION; AXON REGENERATION; NEUROTROPHIC FACTOR; GLIA MATURATION FACTOR-BETA;

D O I：

10.1016/0006-8993(91)91472-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat sciatic nerves were bilaterally transected and repaired with an entubulation technique. The nerve interstump gap was filled with either collagen gel or collagen gel mixed with a putative neurotrophic factor (leupeptin, 4-aminopyridine, lipid angiogenic factor or glia maturation factor beta (GMF-beta)). Six weeks after nerve transection, the myelinated distal stump axons were quantified for each nerve. Only the nerves treated with GMF-beta had significantly more axons than the control side.

引用

页码：332 / 335

页数：4

共 25 条

[1] NEUROMUSCULAR RECOVERY USING CALCIUM PROTEASE INHIBITION AFTER MEDIAN NERVE REPAIR IN PRIMATES [J].