G-PROTEINS MEDIATE INHIBITION AND ACTIVATION OF CA2+-INDUCED EXOCYTOSIS FROM SLO-PERMEABILIZED PEPTIDERGIC NERVE-ENDINGS

被引：4

作者：

AHNERTHILGER, G

DAYANITHI, G

SPICHER, K

NORDMANN, JJ

机构：

[1] CNRS,CTR NEUROCHIM,STRASBOURG,FRANCE

[2] FREE UNIV BERLIN,DEPT PHARMACOL,W-1000 BERLIN 33,GERMANY

来源：

BIOSCIENCE REPORTS | 1992年 / 12卷 / 06期

关键词：

NEUROSECRETION; VASOPRESSIN; GUANINE NUCLEOTIDES; G-PROTEINS;

D O I：

10.1007/BF01122034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In SLO-permeabilized isolated nerve endings from the rat neurohypophysis, GTP, guanosine 5'[y-thio]triphosphate (GTPyS) and guanosine 5'(betay-imido]triphosphate (GMPPNP) inhibit the Ca2+-evoked vasopressin release. Pretreatment with pertussis toxin enhances the inhibitory effects of both GTP-analogues. Omission of Mg2+ overcomes the effect of GMPPNP and reverses the inhibitory effect of GTP and GTPyS. In the absence of Mg2+, GTP and GTPyS now potentiate Ca2+-evoked secretion.

引用

页码：463 / 469

页数：7

共 19 条

[1] EXOCYTOSIS FROM PERMEABILIZED BOVINE ADRENAL CHROMAFFIN CELLS IS DIFFERENTLY MODULATED BY GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE AND GUANOSINE 5'-[BETA-GAMMA-IMIDO]TRIPHOSPHATE [J].