CYP1A2 AND 2E1 EXPRESSION IN RAT-LIVER TREATED WITH COMBINED INDUCERS (3-METHYLCHOLANTHRENE AND ETHANOL)

被引：15

作者：

GOASDUFF, T ^{[1
]}

MENEZ, JF ^{[1
]}

DREANO, Y ^{[1
]}

BERTHOU, F ^{[1
]}

机构：

[1] FAC MED BREST,BIOCHIM NUTR LAB,EQUIPE ACCUEIL DGRT EAD 948,F-29285 BREST,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1841

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of combined ethanol and 3-methylcholanthrene treatment on rat hepatic cytochrome CYP1A2 and CYP2E1 expression were evaluated. Such a treatment attempts to mimic the simultaneous consumption of ethanol and cigarette smoke. Treatments involving 3-methylcholanthrene and combined ethanol + 3-methylcholanthrene decreased both CYP2E1 expression at the mRNA level (0.6 and 0.4 fold versus controls, respectively) and protein level (0.6 and 0.9 fold versus controls, respectively), while dramatically increasing CYP1A2 expression. Furthermore, combined treatment provokes a synergistic induction of CYP1A2 expression as determined by its catalytic activity and protein content. (C) 1995 Academic Press, Inc.

引用

页码：497 / 503

页数：7

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