METHANOL HALF-LIFE DURING ETHANOL ADMINISTRATION - IMPLICATIONS FOR MANAGEMENT OF METHANOL POISONING

被引：42

作者：

PALATNICK, W ^{[1
]}

REDMAN, LW ^{[1
]}

SITAR, DS ^{[1
]}

TENENBEIN, M ^{[1
]}

机构：

[1] UNIV MANITOBA,DEPT EMERGENCY MED,BRANDON,MB,CANADA

来源：

ANNALS OF EMERGENCY MEDICINE | 1995年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(95)70152-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To determine the half-life of methanol in methanol-poisoned patients who are treated with ethanol but not with hemodialysis. Design: Case series. Setting: University Hospital, University of Manitoba. Participants: Three methanol-poisoned patients treated with ethanol but not with hemodialysis and three similar patients identified by a literature review. Results: Plots of terminal concentration versus time data were inconsistent with zero-order kinetics and were adequately explained by an apparent first-order process. The median half-life of methanol in these patients was 43.1 hours, with a range of 30.3 to 52.0 hours. Conclusion: Because of the significantly increased risk of toxicity and complications during ethanol monotherapy, we suggest that hemodialysis be considered far methanal-poisoned patients who are treated with ethanol infusion.

引用

页码：202 / 207

页数：6

共 28 条

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