METABOLISM OF 2-ACETAMIDO-4-(CHLOROMETHYL)THIAZOLE IN GERM-FREE AND CONVENTIONAL RATS

被引：27

作者：

BAKKE, JE

RAFTER, JJ

LINDESKOG, P

FEIL, VJ

GUSTAFSSON, JA

GUSTAFSSON, BE

机构：

[1] USDA SEA, METAB & RADIAT RES LAB, FARGO, ND 58105 USA

[2] KAROLINSKA INST, DEPT GERMFREE RES, S-10401 STOCKHOLM 60, SWEDEN

[3] KAROLINSKA INST, DEPT MED NUTR, S-10401 STOCKHOLM 60, SWEDEN

来源：

BIOCHEMICAL PHARMACOLOGY | 1981年 / 30卷 / 13期

关键词：

D O I：

10.1016/0006-2952(81)90020-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogs by germ-free rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide were proposed. These mechanisms involved the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate metabolized in the intestine to metabolites that were reabsorbed, metabolized and excreted with the urine.

引用

页码：1839 / 1844

页数：6

共 11 条

[1] REPLACEMENT OF A CHLORINE WITH A METHYLSULFONYL GROUP IN METABOLISM OF PROPACHLOR (2-CHLORO-N-ISOPROPYLACETANILIDE) [J].