COMPARATIVE STUDIES ON THE INTERACTION OF VARIOUS TRANSFERRINS AND RAT BONE-MARROW CELLS

被引：13

作者：

VERHOEF, NJ ^{[1
]}

KESTER, HCM ^{[1
]}

NOORDELOOS, PJ ^{[1
]}

LEIJNSE, B ^{[1
]}

机构：

[1] ERASMUS UNIV,FAC MED,DEPT CHEM PATHOL,ROTTERDAM,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1979年 / 10卷 / 07期

关键词：

D O I：

10.1016/0020-711X(79)90021-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. The affinity of bovine transferrin for receptor sites on cell membranes of rat bone marrow cells was found to be much lower than of rat or human transferrin. 2. 2. The apparent Michaelis constant for rat transferrin and bovine transferrin appeared to be 1.25 × 10-6 and 3.2 × 10-6mol/l, respectively. 3. 3. The apparent Michaelis constant for rat transferrin was independent on its iron saturation. The binding at equilibrium of [125I]labelled rat transferrin to rat bone marrow cells varied only slightly with the iron saturation of transferrin. 4. 4. Rat diferric- and monoferric-transferrin had the same affinity for rat bone marrow cell receptors. 5. 5. The affinity of rat apotransferrin for these receptors was about one half of those of diferricand monoferric-transferrin. © 1979.

引用

页码：595 / 602

页数：8

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