SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR-ACTIVITY OF 5-IODOURACIL COMPLEXES

被引：21

作者：

SINGH, UP ^{[1
]}

SINGH, BN ^{[1
]}

GHOSE, AK ^{[1
]}

SINGH, RK ^{[1
]}

SODHI, A ^{[1
]}

机构：

[1] BANARAS HINDU UNIV,FAC SCI,DEPT ZOOL,VARANASI 221005,UTTAR PRADESH,INDIA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1991年 / 44卷 / 04期

关键词：

D O I：

10.1016/0162-0134(91)84033-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.

引用

页码：277 / 282

页数：6

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