AUXOTROPHY OF PSEUDOMONAS-AERUGINOSA IN CYSTIC-FIBROSIS

被引:14
作者
TAYLOR, RFH [1 ]
HODSON, ME [1 ]
PITT, TL [1 ]
机构
[1] CENT PUBL HLTH LAB, LONDON NW9 5HT, ENGLAND
关键词
AUXOTROPHY; PSEUDOMONAS-AERUGINOSA; CYSTIC FIBROSIS;
D O I
10.1111/j.1574-6968.1992.tb05268.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Seventy-four of 403 (18.4%) sputum isolates of Pseudomonas aeruginosa from 49 of 136 (36.0%) adults with cystic fibrosis (CF) were auxotrophic mutants. Two of 11 (18.2%) isolates of P. aeruginosa taken from patients with non-CF bronchiectasis were also auxotrophic. All 99 strains taken from non-bronchiectatic sources were prototrophic. Forty-six of 55 (83.6%) CF auxotrophs required one or more of 36 growth factors tested; the requirements for the remaining 9 isolates were not identified. Methionine was the sole factor required by 17 of 22 (77.3%) isolated which depended on a single factor. We conclude that auxotrophy is a feature of P. aeruginosa infection in cystic fibrosis.
引用
收藏
页码:243 / 246
页数:4
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