AUXOTROPHY OF PSEUDOMONAS-AERUGINOSA IN CYSTIC-FIBROSIS

被引：14

作者：

TAYLOR, RFH ^{[1
]}

HODSON, ME ^{[1
]}

PITT, TL ^{[1
]}

机构：

[1] CENT PUBL HLTH LAB, LONDON NW9 5HT, ENGLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 92卷 / 03期

关键词：

AUXOTROPHY; PSEUDOMONAS-AERUGINOSA; CYSTIC FIBROSIS;

D O I：

10.1111/j.1574-6968.1992.tb05268.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Seventy-four of 403 (18.4%) sputum isolates of Pseudomonas aeruginosa from 49 of 136 (36.0%) adults with cystic fibrosis (CF) were auxotrophic mutants. Two of 11 (18.2%) isolates of P. aeruginosa taken from patients with non-CF bronchiectasis were also auxotrophic. All 99 strains taken from non-bronchiectatic sources were prototrophic. Forty-six of 55 (83.6%) CF auxotrophs required one or more of 36 growth factors tested; the requirements for the remaining 9 isolates were not identified. Methionine was the sole factor required by 17 of 22 (77.3%) isolated which depended on a single factor. We conclude that auxotrophy is a feature of P. aeruginosa infection in cystic fibrosis.

引用

页码：243 / 246

页数：4

共 14 条

[1]

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[2]

CATLIN BW, 1989, J GEN MICROBIOL, V135, P1101

[3]

CLOWES RC, 1968, EXPT MICROBIAL GENET, P184

[4]

Govan JR, 1990, REV MED MICROBIOL, V1, P19