LOSS OF CONSTITUTIONAL HETEROZYGOSITY ON CHROMOSOME-5 AND CHROMOSOME-17 IN CHOLANGIOCARCINOMA

被引：25

作者：

DING, SF

DELHANTY, JDA

BOWLES, L

DOOLEY, JS

WOOD, CB

HABIB, NA

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,DU CANE RD,LONDON W12 0NN,ENGLAND

[2] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT SURG,LONDON NW3 2QG,ENGLAND

[3] UNIV LONDON UNIV COLL,DEPT GENET,LONDON NW1 2HE,ENGLAND

[4] UNIV LONDON UNIV COLL,DEPT BIOMETRY,LONDON NW1 2HE,ENGLAND

[5] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT MED,LONDON NW3 2QG,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 67卷 / 05期

关键词：

D O I：

10.1038/bjc.1993.184

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholangiocarcinoma, we studied 14 patients with this tumour using restriction fragment length polymorphism analysis. Twenty-two probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. Allelic losses were found in chromosomal regions 5q35-qter and 17p13. Loss of genetic material in these regions in cholangiocarcinoma was shared with hepatocellular carcinoma. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, this study for the first time showed LOH on chromosomes 5 and 17 in cholangiocarcinoma.

引用

页码：1007 / 1010

页数：4

共 34 条

[1] SEQUENCES FLANKING THE REPEAT ARRAYS OF HUMAN MINISATELLITES - ASSOCIATION WITH TANDEM AND DISPERSED REPEAT ELEMENTS [J].