RANDOMIZED PLACEBO-CONTROLLED TRIAL OF RECOMBINANT INTERLEUKIN-2 IN CHRONIC UREMIC PATIENTS WHO ARE NONRESPONDERS TO HEPATITIS-B VACCINE

被引:58
作者
JUNGERS, P
DEVILLIER, P
SALOMON, H
CERISIER, JE
COUROUCE, A
机构
[1] ROUSSEL UCLAF,DEPT IMMUNOL,ROMAINVILLE,FRANCE
[2] PASTEUR MERLEUX,SERUMS & VACCINS,DEPT MED,MARNES COQUETTE,FRANCE
[3] INST NATL TRANSFUS SANGUINE,F-75015 PARIS,FRANCE
关键词
D O I
10.1016/S0140-6736(94)92829-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Natural interleukin-2 at low dose has been reported to overcome the non-responsiveness of patients with chronic uraemia to hepatitis B vaccine. Therefore, we revaccinated 52 previous such non-responders (24 on maintenance dialysis) with 20 mu g of recombinant preS2-containing hepatitis B vaccine with human recombinant interleukin-2 (1 MU) or placebo (randomly allocated). Seroconversion rates (74 vs 80%, respectively) and proportion of patients who elicited anti-HBs titres of 10 mlU/mL or more (56 vs 68%) were similar in both groups. Our results do not confirm local injection of interleukin-2 as an effective immunoadjuvant to hepatitis B vaccine in uraemic patients.
引用
收藏
页码:856 / 857
页数:2
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