IMPAIRED POLYMORPHONUCLEAR NEUTROPHIL FUNCTION IN END-STAGE RENAL-FAILURE AND ITS CORRECTION BY CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

被引：19

作者：

PORTER, CJ ^{[1
]}

BURDEN, RP ^{[1
]}

MORGAN, AG ^{[1
]}

DANIELS, I ^{[1
]}

FLETCHER, J ^{[1
]}

机构：

[1] NOTTINGHAM CITY HOSP TRUST,DEPT RENAL MED,NOTTINGHAM NG5 1PB,ENGLAND

来源：

NEPHRON | 1995年 / 71卷 / 02期

关键词：

BACTERIAL KILLING; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; END-STAGE RENAL FAILURE; PHAGOCYTOSIS; POLYMORPHONUCLEAR NEUTROPHILS; SUPEROXIDE ANION;

D O I：

10.1159/000188700

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The polymorphonuclear neutrophil (PMN) function of 22 patients with endstage renal failure (ESRF) was studied immediately before and 3 months after starting continuous ambulatory peritoneal dialysis (CAPD) and compared with a control group of healthy normal volunteers. The PMN functions studied were phagocytosis and killing of Staphylococcus epidermidis and respiratory burst activity. The results show that in the presence of normal pooled human serum PMN from patients with ESRF before CAPD treatment phagocytose bacteria normally, but have impaired killing. Before treatment, the PMN from patients with ESRF also showed an increase in both unstimulated and stimulated superoxide anion production. Abnormal PMN function was corrected by CAPD treatment, suggesting the involvement of a dialyzable toxin.

引用

页码：133 / 137

页数：5

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