共 3 条
- [1] MIZUNO Y, 1963, J ORG CHEM, V28, P3329, DOI 10.1021/jo01047a012
- [2] OKHUMA K, 1961, J ANTIBIOT TOKYO, VA 14, P343
- [3] Rao KV, 1963, ANTIMICROB AGENTS CH, P77
STRUCTURE OF SANGIVAMYCIN
被引：59
作者：
RAO, KV
机构：
[1] John L. Smith Memorial for Cancer Research, Chas. Pfizer & Co., Inc., Maywood, New Jersey
关键词：
D O I：
10.1021/jm00311a005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sangivamycin is an antitumor substance and a metabolite of a streptomycete culture. It has the molecular formula C12H15N5O5 and shows spectral properties similar to those of nucleosides. The presence of a pentose residue was established indirectly by periodate oxidation and hydrolysis. The compound also has an aromatic amino group and a carboxamide group. Some of the similarities in properties to toyocamycin led to the hypothesis that sangivamycin may be closely related to this compound. This hypothesis is shown to be correct in that sangivamycin has a carboxamide group and toyocamycin has a nitrile group on the same carbon skeleton. This relationship is established by three different methods. A brief study of the biological activity of some of the derivatives of sangivamycin is described. © 1968, American Chemical Society. All rights reserved.
引用
收藏
页码：939 / &
相关论文