CHARACTERIZATION OF AN APPARENTLY NONONCOGENIC MAREKS-DISEASE VIRUS

被引：217

作者：

SCHAT, KA

CALNEK, BW

机构：

[1] Department of Avian and Aquatic Animal Medicine, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1978年 / 60卷 / 05期

关键词：

D O I：

10.1093/jnci/60.5.1075

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new isolate of Marek’s disease virus (MDV) was described. This virus, SB, and a clone, SB-1, differed from pathogenic isolates in in vitro growth characteristics as described for other apathogenic isolates. Serologically, as with other apathogenic isolates, SB could be distinguished from pathogenic MDV and the avirulent turkey herpesvirus. SB failed to induce lesions characteristic of Marek’s disease (MD) during a 6- to 11-week experimental period. Also, SB was nononcogenic in immunosuppressed chickens or in chickens inoculated with this virus in ovo. However, under those conditions, SB caused a cytolytic infection. The term “nononcogenic” rather than “apopathogenic” was therefore proposed to classify this and similar isolates. SB-1 protected chickens against challenge with either virulent MDV or the non-virus-producing MD tumor transplant, JMV. Possible mechanisms of protection are discussed. © 1978 Oxford University Press. All rights reserved.

引用

页码：1075 / 1082

页数：8

共 46 条

[1] GLUTARALDEHYDE CYANURIC CHLORIDE AND TETRAAZOTIZED O-DIANISISDINE AS COUPLING REAGENTS IN PASSIVE HEMAGGLUTINATION TEST [J].

AVRAMEAS, S ;

TAUDOU, B ;

CHUILON, S .

IMMUNOCHEMISTRY, 1969, 6 (01) :67-&

[2]

Biggs P. M., 1972, Oncogenesis and herpesviruses. Proceedings of a symposium held at Christ's College, Cambridge, England 20 to 25 June 1971., P88

[3]

Bulow V V, 1975, Avian Pathol, V4, P147, DOI 10.1080/03079457509353860

[4]

Bulow V V, 1975, Avian Pathol, V4, P133, DOI 10.1080/03079457509353859

[5]

BULOW VV, 1975, ONCOGENESIS HERPESVI, V2, P329

[6] PATHOGENICITY OF LOW-VIRULENCE MAREKS-DISEASE VIRUSES IN NORMAL VERSUS IMMUNOLOGICALLY COMPROMISED CHICKENS [J].

CALNEK, BW ;

FABRICANT, J ;

SCHAT, KA ;

MURTHY, KK .

AVIAN DISEASES, 1977, 21 (03) :346-358

[7] INFLUENCE OF AGE AT EXPOSURE ON PATHOGENESIS OF MAREKS-DISEASE [J].

CALNEK, BW .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (03) :929-939

[8] FEATHER FOLLICLE EPITHELIUM - A SOURCE OF ENVELOPED AND INFECTIOUS CELL-FREE HERPESVIRUS FROM MAREKS DISEASE [J].

CALNEK, BW ;

ADLDINGER, HK ;

KAHN, DE .

AVIAN DISEASES, 1970, 14 (02) :219-+

[9] EFFECTS OF PASSIVE ANTIBODY ON EARLY PATHOGENESIS OF MAREKS-DISEASE [J].

CALNEK, BW .

INFECTION AND IMMUNITY, 1972, 6 (02) :193-&

[10] LYOPHILIZATION OF CELL-FREE MAREKS DISEASE HERPESVIRUS AND A HERPESVIRUS FROM TURKEYS [J].

CALNEK, BW ;

HITCHNER, SB ;

ADLDINGER, HK .

APPLIED MICROBIOLOGY, 1970, 20 (05) :723-+

← 1 2 3 4 5 →