HOMOLYTIC CONSTANTS IN CORRELATION OF CHLORAMPHENICOL STRUCTURE WITH ACTIVITY

Homolytic constants are found to give a better structure-activity correlation for chloramphenicol derivatives than either the usual Hammett constant or polarizability constants. Evidence is presented indicating that, a variety of aromatic methanol derivatives which are active as drugs are involved in interference at the molecular level with free-radical enzymes. © 1969, American Chemical Society. All rights reserved.