CLOMIPRAMINE HYDROCHLORIDE IN CHILDHOOD AND ADOLESCENT OBSESSIVE-COMPULSIVE DISORDER - A MULTICENTER TRIAL

被引：206

作者：

DEVEAUGHGEISS, J

MOROZ, G

BIEDERMAN, J

CANTWELL, D

FONTAINE, R

GREIST, JH

REICHLER, R

KATZ, R

LANDAU, P

机构：

[1] UNIV WASHINGTON, HARBORVIEW MED CTR, SEATTLE, WA 98104 USA

[2] CIBA GEIGY AG, PHARMACEUT, CH-4002 BASEL, SWITZERLAND

[3] MASSACHUSETTS GEN HOSP, BOSTON, MA 02114 USA

[4] UNIV CALIF LOS ANGELES, INST NEUROPSYCHIAT, LOS ANGELES, CA 90024 USA

[5] LOUIS H LAFONTAINE HOSP, MONTREAL H1N 3M5, QUEBEC, CANADA

[6] UNIV WISCONSIN, SCH MED, MADISON, WI 53706 USA

[7] CIBA GEIGY CORP, PHARMACEUT, SUMMIT, NJ 07901 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 1992年 / 31卷 / 01期

关键词：

OBSESSIVE-COMPULSIVE DISORDER; CLOMIPRAMINE; OBSESSION; COMPULSION; Y-BOCS;

D O I：

10.1097/00004583-199201000-00008

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Children and adolescents with obsessive compulsive disorder were studied in an 8-week, multicenter, double-blind, parallel groups trial of clomipramine hydrochloride (CMI) versus placebo. Efficacy assessments included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global rating scale. At the end of 8 weeks, CMI-treated patients showed a mean reduction in Yale-Brown Obsessive Compulsive Scale score of 37% compared to 8% in the placebo group. Side effects were typical of tricyclic antidepressants. In a 1-year open label treatment, CMI continued to be effective and well tolerated.

引用

页码：45 / 49

页数：5

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