CONTRIBUTION OF GLYCOPROTEINS TO FIBRINOGEN-INDUCED AGGREGATION OF ERYTHROCYTES

被引：21

作者：

MAEDA, N ^{[1
]}

SEIKE, M ^{[1
]}

NAKAJIMA, T ^{[1
]}

IZUMIDA, Y ^{[1
]}

SEKIYA, M ^{[1
]}

SHIGA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT PHYSIOL,KITA KU,OSAKA,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1022卷 / 01期

关键词：

(Human erythrocyte); Band; 3; Erythrocyte aggregation; Erythrocyte deformability; Sialoglycoprotein;

D O I：

10.1016/0005-2736(90)90401-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The contribution of membrane glycoproteins to the velocity of fibrinogen-induced erythrocyte aggregation was examined using a rheoscope combined with a video camera, an image analyzer and a computer. The structure of glycoproteins was modified with proteolytic enzymes, trypsin or α-chymotrypsin. (1) Mild enzymatic treatment of erythrocytes decreased the velocity of erythrocyte aggregation, but more intense treatment increased the velocity remarkably. (2) The erythrocyte aggrgation was affected not only by the density of surface negative charge of erythrocytes, but also by the structural changes of glycoproteins. (3) Erythrocyte deformability and the morphological characteristics were not altered by these enzymatic treatments. The physiological significance of glycoproteins of erythrocyte surface for the survival of erythrocytes and for the suspension stability of blood was discussed. © 1990.

引用

页码：72 / 78

页数：7

共 43 条

[1] 2 INDIVIDUALS WITH ELLIPTOCYTIC RED-CELLS APPARENTLY LACK 3 MINOR ERYTHROCYTE-MEMBRANE SIALOGLYCOPROTEINS [J].