A NOVEL AND CONCISE SYNTHESIS OF AMINOCYCLOPENTITOLS AND 1-DEOXYNOJIRIMYCIN VIA RADICAL CYCLIZATION OF OXIME ETHERS

被引：68

作者：

KIGUCHI, T

TAJIRI, K

NINOMIYA, I

NAITO, T

HIRAMATSU, H

机构：

[1] KOBE PHARMACEUT UNIV,KOBE 658,JAPAN

[2] TANABE SEIYAKU CO LTD,RES LAB,TODA,SAITAMA 335,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02185-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tributyltin hydride-induced radical cyclization of the oxime ether 3 derived from D-glucose proceeded smoothly to give two amino alcohols 4 and 5 which were converted into two aminocyclopentitol pentaacetates 8 and 12 and 1-deoxynojirimycin known as glycosidase inhibitors.

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页码：253 / 256

页数：4

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