Circular RNA expands its territory

被引：60

作者：

Bao, Chunyang ^{[1
,2
,3
]}

Lyu, Dongbin ^{[1
,2
,3
]}

Huang, Shenglin ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Cancer biomaker; circular RNA; exosomes; microRNA; non-coding RNA;

D O I：

10.1080/23723556.2015.1084443

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Circular RNAs (circRNAs) represent a novel class of widespread non-coding RNAs in eukaryotes. They are unusually stable RNA molecules with cell type-specific expression patterns, and are predominantly present in the cytoplasm. We recently demonstrated the existence of abundant circRNAs in exosomes and suggest a potential application of exosomal circRNAs for cancer detection.

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页数：2

相关论文

共 9 条

[1]

Regulation of circRNA biogenesis [J].

Chen, Ling-Ling ;

Yang, Li .

RNA BIOLOGY, 2015, 12 (04) :381-388

[2]

The RNA Binding Protein Quaking Regulates Formation of circRNAs [J].

Conn, Simon J. ;

Pillman, Katherine A. ;

Toubia, John ;

Conn, Vanessa M. ;

Salmanidis, Marika ;

Phillips, Caroline A. ;

Roslan, Suraya ;

Schreiber, Andreas W. ;

Gregory, Philip A. ;

Goodall, Gregory J. .

CELL, 2015, 160 (06) :1125-1134

[3]

circBase: a database for circular RNAs [J].

Glazar, Petar ;

Papavasileiou, Panagiotis ;

Rajewsky, Nikolaus .

RNA, 2014, 20 (11) :1666-1670

[4]

Natural RNA circles function as efficient microRNA sponges [J].

Hansen, Thomas B. ;

Jensen, Trine I. ;

Clausen, Bettina H. ;

Bramsen, Jesper B. ;

Finsen, Bente ;

Damgaard, Christian K. ;

Kjems, Jorgen .

NATURE, 2013, 495 (7441) :384-388

[5]

Detecting and characterizing circular RNAs [J].

Jeck, William R. ;

Sharpless, Norman E. .

NATURE BIOTECHNOLOGY, 2014, 32 (05) :453-461

[6]

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis [J].

Li, Yan ;

Zheng, Qiupeng ;

Bao, Chunyang ;

Li, Shuyi ;

Guo, Weijie ;

Zhao, Jiang ;

Chen, Di ;

Gu, Jianren ;

He, Xianghuo ;

Huang, Shenglin .

CELL RESEARCH, 2015, 25 (08) :981-984

[7]

Circular RNAs are a large class of animal RNAs with regulatory potency [J].

Memczak, Sebastian ;

Jens, Marvin ;

Elefsinioti, Antigoni ;

Torti, Francesca ;

Krueger, Janna ;

Rybak, Agnieszka ;

Maier, Luisa ;

Mackowiak, Sebastian D. ;

Gregersen, Lea H. ;

Munschauer, Mathias ;

Loewer, Alexander ;

Ziebold, Ulrike ;

Landthaler, Markus ;

Kocks, Christine ;

le Noble, Ferdinand ;

Rajewsky, Nikolaus .

NATURE, 2013, 495 (7441) :333-338

[8]

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed [J].

Rybak-Wolf, Agnieszka ;

Stottmeister, Christin ;

Glazar, Petar ;

Jens, Marvin ;

Pino, Natalia ;

Giusti, Sebastian ;

Hanan, Mor ;

Behm, Mikaela ;

Bartok, Osnat ;

Ashwal-Fluss, Reut ;

Herzog, Margareta ;

Schreyer, Luisa ;

Papavasileiou, Panagiotis ;

Ivanov, Andranik ;

Ohman, Marie ;

Refojo, Damian ;

Kadener, Sebastian ;

Rajewsky, Nikolaus .

MOLECULAR CELL, 2015, 58 (05) :870-885

[9]

Exosomes in cancer: small particle, big player [J].

Zhang, Xu ;

Yuan, Xiao ;

Shi, Hui ;

Wu, Lijun ;

Qian, Hui ;

Xu, Wenrong .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 8