ACTH4-10 ANTAGONISM OF MORPHINE-INDUCED BEHAVIORAL ACTIVATION IN THE MOUSE

被引：20

作者：

KATZ, RJ

机构：

[1] Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 53卷 / 04期

关键词：

ACTH[!sub]4-10[!/sub; Behavioral activation; Morphine; Psychomotor activity;

D O I：

10.1016/0014-2999(79)90464-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 4-10 fragment of adrenocorticotrophic hormone (ACTH4-10; Met-Glu-His-Phe-Arg-Trp-Gly) was administered intracerebroventricularly to C57Bl mice with and without concurrent systemic injection of a standard dose of morphine sulfate. Morphine produced stereotyped behavioral activation (running, environmental oblivion, Straub tail) which was antagonized in a dose related fashion by the ACTH fragment. This extends the range of opiate-ACTH4-10 interactions to a novel species and behavioral model, and is consistent with previous findings. © 1979.

引用

页码：383 / 385

页数：3