ERYTHROCYTE MEMBRANE STABILIZATION AND PROTEIN BINDING OF SOME ANTI-INFLAMMATORY DRUGS AND OF DEOXYCHOLIC ACID

被引：22

作者：

CATANESE, B

LISCIANI, R

PICCINELLI, D

机构：

[1] Institute of Pharmacology and Phannacognosy, Faculty of Pharmacy, University of Rome

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 07期

关键词：

D O I：

10.1016/0006-2952(69)90160-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stabilizing activity of indomethacin and phenylbutazone on red cells in aqueous solutions has been confirmed. The same activity, together with a hemolytic effect at higher concentrations, has been observed for deoxycholic acid and benzydamine. The activity of benzydamine and phenylbutazone remain practically unchanged in the presence of serum, whereas with indomethacin and deoxycholic acid, serum produced a sharp decrease in activity. The latter results were found to correlate with the different capacity of the substances to bind serum proteins. © 1969.

引用

页码：1707 / +

页数：1

共 9 条

[1]

BURNS JJ, 1953, J PHARMACOL EXP THER, V109, P346

[2]

CATANESE B, 1966, ARZNEI-FORSCHUNG, V16, P1354

[3]

HUCKER HB, 1966, J PHARMACOL EXP THER, V153, P237

[4]

INGLOT AD, 1968, BIOCHEM PHARMACOL, V17, P269