TFMPP AND RU24969 ENHANCE SEROTONIN RELEASE FROM RAT HIPPOCAMPUS

被引：36

作者：

AUERBACH, SB

KAMALAKANNAN, N

RUTTER, JJ

机构：

[1] Department of Biological Sciences. Rutgers University., Piscataway, NJ 08855-1059

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 190卷 / 1-2期

关键词：

5-HT; (5-hydroxytryptaminne; serotonin); RU 24969 (5-methoxy-3-(l,2,3,6-tetrahydro-4-pyridinyl)-1H-indole); TFMPP (1 -(3-(trifluoromethyl)phenyl]piperazine);

D O I：

10.1016/0014-2999(90)94111-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using a batch method for incubation of hippocampal slices, we have examined the effects of 5-methoxy-3-(l,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU24969) and (m-trifluoromethylphenyl)piperazine (TFMPP) on release of endogenous 5-hydroxytryptamine (5-HT). Release of 5-HT from slices was enhanced by RU24969 and TFMPP at concentrations from 1 to 10 μmol. The 5-HT uptake inhibitors imipramine and fluoxetine, but not the autoreceptor antagonist methiothepui, blocked the enhancement in 5-HT. These results suggest that RU24969 and TFMPP, previously identified as potent agonists at the nerve terminal autoreceptor, also interact at higher concentrations with the reuptake carrier to enhance extracellular levels of 5-HT. © 1990.

引用

页码：51 / 57

页数：7

共 30 条

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