INCREASE IN THE CYTOSOLIC CONCENTRATION OF CALCIUM IN PLATELETS OF DIABETICS TYPE-II

被引：41

作者：

TSCHOPE, D ^{[1
]}

ROSEN, P ^{[1
]}

GRIES, FA ^{[1
]}

机构：

[1] DIABET FORSCHUNGSINST,AUF HENNEKAMP 65,W-4000 DUSSELDORF,GERMANY

来源：

THROMBOSIS RESEARCH | 1991年 / 62卷 / 05期

关键词：

PLATELET AGGREGATION; DIABETES-MELLITUS; CALCIUM; CALCIUM ANTAGONISTS;

D O I：

10.1016/0049-3848(91)90015-O

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intracellular concentration of calcium (Ca(i)) was measured in platelets of healthy control subjects and diabetics type II. Ca(i) was elevated in platelets of diabetics type II under basal conditions, after stimulation by collagen, in the presence and absence of calcium in the incubation medium. The increase in Ca(i) after stimulation by collagen was inhibited by nitrendipine in both kinds of platelets, however Ca(i) remained elevated in platelets of diabetics. our data and findings of others may be understood as indications of disturbances in the handling of Ca(i) in diabetes.

引用

页码：421 / 428

页数：8

共 27 条

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