SYNTHESIS OF NEW PHOSPHOLIPIDS LINKED TO STEROID-HORMONE DERIVATIVES DESIGNED FOR 2-DIMENSIONAL CRYSTALLIZATION OF PROTEINS

被引：50

作者：

LEBEAU, L ^{[1
]}

OUDET, P ^{[1
]}

MIOSKOWSKI, C ^{[1
]}

机构：

[1] FAC MED,CNRS,GENET MOLEC EUCARYOTES LAB,INSERM,UNITE 184 BIOL MOLEC & GENIE GENET,F-67085 STRASBOURG,FRANCE

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 08期

关键词：

D O I：

10.1002/hlca.19910740810

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of phospholipids 1n-3n, rationally designed for two-dimensional crystallization of progesterone and estradiol receptors, is reported. The structure of these lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H2O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.

引用

页码：1697 / 1706

页数：10

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