METHYL-GAG, IFOSFAMIDE, METHOTREXATE AND ETOPOSIDE (MIME) AS SALVAGE THERAPY FOR HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA

One hundred and three patients with recurrent or refractory Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) treated with MIME (methyl-GAG, ifosfamide, methotrexate, etoposide) were retrospectively studied. Thirty-seven of the 44 patients with HD, 34/47 with high-grade malignant and 9/12 with low-grade malignant NHL were evaluable for response. of the 37 evaluable patients with HD, 16 (43% achieved complete remission (CR) and 4 partial remission (PR), giving a total response rate of 54% of the 34 evaluable patients with high-grade NHL, 5 achieved CR and 8 PR, giving a response rate of 38% of 9 evaluable patients with low-grade NHL, 2 achieved CR. The main toxicity was leukopenia, trombocytopenia and infections. Twentysix per cent of the patients developed septicaemia, which was fatal in 6 cases (6% We conclude that MIME as salvage regimen can induce complete remissions in lymphoma patients, particularly in HD with previous heavy treatment, and that it is relatively well tolerated. ©1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.