MODIFICATION OF ACCESSORY ACTIVITY OF SHEEP MONOCYTES INVITRO BY A COENURUS ANTIGEN FROM TAENIA-MULTICEPS

被引:7
作者
RAKHA, NK
DIXON, JB
SKERRITT, GC
CARTER, SD
JENKINS, P
机构
[1] UNIV LIVERPOOL,DEPT VET PATHOL,LIVERPOOL L69 3BX,ENGLAND
[2] UNIV LIVERPOOL,DEPT VET PRECLIN SCI,LIVERPOOL L69 3BX,ENGLAND
[3] UNIV LIVERPOOL,DEPT VET CLIN SCI,LIVERPOOL L69 3BX,ENGLAND
关键词
D O I
10.1016/0165-2427(92)90145-G
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A factor in Taenia multiceps coenurus fluid (TMCF) has previously been shown to modify the accessory activity of murine macrophages in vivo and in vitro. The factor (TMCF-F24) has been purified by ion exchange in a fast protein liquid chromatography (FPLC) system. This study was conducted to determine whether TMCF-F24 is an antigen in naturally occurring cerebral coenuriasis, and whether it can also modify normal sheep blood monocytes. Specific IgG antibodies to TMCF-F24 were detected, using ELISA, in serum and cerebrospinal fluid of sheep with clinical coenuriasis. Alterations in monocyte accessory activity were detected by an assay which measured the rate of increase in mitogen-induced lymphocyte transformation caused by addition of increasing numbers of the monocytes. Normal monocytes caused a positive increase in lymphocyte transformation. Monocytes incubated with TMCF-F24 caused progressive inhibition of transformation. This factor may therefore modify monocyte-T cell interaction in natural infection.
引用
收藏
页码:293 / 304
页数:12
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