AUTOSOMAL DOMINANT GENE TRANSMISSION IN A LARGE KINDRED WITH GILLES-DE-LA-TOURETTE SYNDROME

被引：62

作者：

CURTIS, D ^{[1
]}

ROBERTSON, MM ^{[1
]}

GURLING, HMD ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,MIDDLESEX HOSP,ACAD DEPT PSYCHIAT,RIDING HOUSE ST,LONDON W1P 7PN,ENGLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1992年 / 160卷

关键词：

D O I：

10.1192/bjp.160.6.845

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

A multiplex kindred ascertained through a single proband with GTS has been systematically investigated with standardised diagnostic instruments for other cases of GTS and related disorders. Complex segregation analysis supported the hypothesis that a single major gene inherited in autosomal dominant fashion but with incomplete penetrance contributed most of the variance in the liability to develop GTS and related disorders. This result is consistent with previous segregation analyses which have employed different methods of ascertainment, and tends to confirm that a proportion of GTS is due to a dominant gene and is suitable for investigation with genetic markers for linkage analysis.

引用

页码：845 / 849

页数：5

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