INHIBITION OF ALLERGIC BRONCHOCONSTRICTION IN GUINEA-PIGS AND IN ASTHMATICS BY THE LEUKOTRIENE ANTAGONIST ONO-1078

被引：3

作者：

NAKAGAWA, T

YAMASHITA, N

MIZUSHIMA, Y

ISHII, A

ITO, K

NAMBU, F

MOTOISHI, M

YUI, Y

SHIDA, T

MIYAMOTO, T

机构：

[1] UNIV TOKYO,TOKYO 113,JAPAN

[2] ONO PHARMACEUT CO LTD,RES INST,MISHIMA,OSAKA 618,JAPAN

[3] NATL SAGAMIHARA HOSP & RES CTR RHEUMATOL ALLERGY,SAGAMIHARA,JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 99卷 / 2-4期

关键词：

BRONCHIAL ASTHMA; BRONCHIAL PROVOCATION TEST; LEUKOTRIENE ANTAGONIST; LUNG ANAPHYLAXIS;

D O I：

10.1159/000236321

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effect of the leukotriene receptor antagonist ONO-1078 on experimental and clinical bronchial asthma was evaluated. It was found that this compound could inhibit antigen-induced bronchoconstriction in passively sensitized guinea pigs and leukotriene D4- and allergen-induced bronchial responses in normal and in asthmatic subjects. Clinical trials in patients with chronic bronchial asthma demonstrated its effectiveness in reducing hazardous symptoms like wheezing and dyspneic attacks.

引用

页码：490 / 492

页数：3

共 8 条

[1] INHIBITION OF ENDOGENOUS LEUKOTRIENE-MEDIATED LUNG ANAPHYLAXIS IN GUINEA-PIGS BY A NOVEL RECEPTOR ANTAGONIST ONO-1078 [J].