DIFFERENCE IN TL-201 ACCUMULATION ON SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN BENIGN AND MALIGNANT THORACIC LESIONS

被引：32

作者：

SUGA, K

KUME, N

ORIHASHI, N

NISHIGAUCHI, K

UCHISAKO, H

MATSUMOTO, T

YAMADA, N

NAKANISHI, T

机构：

[1] Department of Radiology, Yamaguchi University School of Medicine, Ube, Yamaguchi

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1993年 / 14卷 / 12期

关键词：

D O I：

10.1097/00006231-199312000-00004

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The difference in Tl-201-chloride (Tl-201) accumulation on single photon emission computed tomography (SPECT) between 58 benign (58 cases) and 48 malignant (46 cases) thoracic lesions, each of more than 20 mm in diameter was investigated. In the 34 benign and 48 malignant lesions depicted in both early (15 min) and delayed (3 h) images there was no significant difference in the mean early and delayed uptake ratios of lesion to normal contralateral lung between benign and malignant. However, the retention index in the lesion derived from (delayed ratio - early ratio)/(early ratio) x 100% showed a significant difference (benign -4.30 +/- 13.6% versus malignant 23.3 +/- 18.9%, P < 0.01), indicating the poor Tl-201 retention in the benign lesions. Using the criteria of nondepiction in the delayed image or a negative retention index, 81.1% accuracy and 95.2% predictive value for diagnosis of benign lesions were obtained. Thus, Tl-201 SPECT appears to have potential usefulness in the diagnosis of benign thoracic lesions.

引用

页码：1071 / 1078

页数：8

共 18 条

[1]

Matsuno S., Tanabe M., Kawasaki Y., Satoh K., Urrutia A.E., Ohkawa M., Maeda M., Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer, Eur J Nucl Med, 19, pp. 886-895, (1992)

[2]

Tonami N., Shuke N., Yokoyama K., Seki H., Takayama T., Kinuya S., Nakajima K., Aburano T., Hisada K., Watanabe Y., Thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer, J Nucl Med, 30, pp. 997-1004, (1989)

[3]

Orihashi N., Suga K., Yoneshiro S., Evaluation of Tl-201 SPECT in differential diagnosis of benign and malignant lesions of the chest, Yamaguchi Med J, 41, pp. 275-283, (1992)

[4]

Tonami N., Yokoyama K., Taki J., Shuke N., Kinuya S., Nakajima K., Michigishi T., Aburano T., Hisada K., Watanabe Y., Takashima T., Nonomura A., A 201T1 SPECT in the detection of mediastinal lymph node metastases from lung cancer, Nucl Med Commun, 12, pp. 779-792, (1991)

[5]

Salvatore M., Carratu L., Porta E., Thallium-201 as a positive indicator for lung neoplasms: Preliminary experiments, Radiology, 49, pp. 767-768, (1976)

[6]

Ando A., Ando I., Katayama M., Biodistribution of 201T1 in tumor bearing animals and inflammatory lesion induced animals, Eur J Nucl Med, 12, pp. 567-572, (1987)

[7]

Sindo T., Okabe T., Inui K., Et al., Clincal evaluation of 201T1 scintigraphy with bronchial arterial administration, Jpn J Clin Radiol, 30, pp. 1529-1536, (1985)

[8]

Ochi H., Sawa H., Fukuda T., Inoue Y., Nakajima H., Masuda Y., Okamura T., Onoyama T., Sugano S., Ohkita H., Tei Y., Kamino K., Kobayashi Y., Thallium-201 chloride thyroid scintigraphy to evaluate benign and/or malignant nodules-usefulness of the delayed scan, Cancer, 50, pp. 236-240, (1982)

[9]

Sehweil A.M., Mc killop J.H., Milroy R., Sayed M.A., Ziada G., Banham S.W., Davidson K.G., Ragib A., Omar Y.T., Abdel- Dayem HM. 201T1 scintigraphy in the staging of lung cancer, breast cancer, and lymphoma, Nucl Med Commun, 11, pp. 263-269, (1990)

[10]

Elligsen J.D., Thompson J.E., Frey H.E., Correlation of (Na+- K+) ATPase activity with growth of normal and transformed cells, Exp Cell Res, 87, pp. 233-240, (1974)

← 1 2 →