SYNTHESIS OF 3-(N-ALKYLAMINO)ACETOPHENONES VIA A BENZYNE INTERMEDIATE

被引：4

作者：

ALBRIGHT, JD

LIEBERMAN, DF

机构：

[1] American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, New York

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 02期

关键词：

D O I：

10.1002/jhet.5570310247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 2-(2-bromophenyl)-2-methyl-1,3-dioxolane with lithium (1,1-dimethylethyl)amide, lithium (2,2-dimethylpropyl)amide, lithium (1,1-dimethylpropyl)amide gave the corresponding N-(alkyl)-3-(2-methyl-1,3-dioxolan-2-yl)benzenamines in moderate yields. 1-[3-[(1,1-Dimethylethyl)amino]phenyl]ethanone (4) was prepared in over 80% yield from 2-(2-bromophenyl)-2-methyl-1,3-dioxolane (2).

引用

页码：537 / 539

页数：3

共 6 条

[1]

ALBRIGHT JD, 1990, Patent No. 4892873

[2]

ALBRIGHT JD, 1981, J MED CHEM, V24, P591

[3]

BEUGELMANS R, 1987, J ORG CHEM, V52, P3882

[4] A NEW AND IMPROVED SYNTHESIS OF 6-ARYL-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINES [J].