ROLE OF THE CYCLOSPORINE-A CYCLOPHILIN COMPLEX, FK506-FK506-BINDING PROTEIN COMPLEX AND CALCINEURIN IN THE INHIBITION OF T-CELL SIGNAL-TRANSDUCTION

被引：9

作者：

ETZKORN, FA

STOLZ, LA

CHANG, ZY

WALSH, CT

机构：

[1] FA Etzkorn, LA Stolz, Z. Chang and CT Walsh, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/0959-440X(93)90158-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of immunosupressive drug action and intracellular signalling continues to advance. The structures of new immunophilin-immunosuppressant drug complexes have been formed by the immunophilin-drug complexes and calcineurin are being made by mutagenesis and by the comparison of various protein isotypes. Since the inhibition of calcineurin by the immunophilin-drug complex has been shown to interfere with nuclear localization of NFAT (nuclear factor for activation of T cells), our understanding of the intracellular signal for immune response has become more detailed.

引用

页码：929 / 933

页数：5

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