PLANTS AS SOURCES OF ANTIMALARIAL-DRUGS .4. ACTIVITY OF BRUCEA-JAVA']JAVANICA FRUITS AGAINST CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM INVITRO AND AGAINST PLASMODIUM-BERGHEI INVIVO

被引：91

作者：

ONEILL, MJ ^{[1
]}

BRAY, DH ^{[1
]}

BOARDMAN, P ^{[1
]}

CHAN, KL ^{[1
]}

PHILLIPSON, JD ^{[1
]}

WARHURST, DC ^{[1
]}

PETERS, W ^{[1
]}

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED, DEPT MED PROTOZOOL, LONDON WC1E 7HT, ENGLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1987年 / 50卷 / 01期

关键词：

D O I：

10.1021/np50049a007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts of Brucea javanica fruit have been prepared and monitored for their in vitro and in vitro antiplasmodial activities. The antimalarial activity of the fruit was found to be attributable to its quassinoid constituents. Nine of the quassinoids possessed in vitro IC50 values between 0.046-0.0008 .mu.g/ml against the chloroquine resistant Plasmodium falciparum strain (Kl) tested. The two quassinoid glycosides tested were considerably less active in vitro than the aglycones. Four quassinoids were found to possess activity in vivo against Plasmodium berghei infections in mice after oral dosing. All five quassinoids tested in vivo showed some toxicity.

引用

页码：41 / 48

页数：8

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