INDOBUFEN, A NEW INHIBITOR OF PLATELET-AGGREGATION - STUDIES IN GUINEA-PIGS

被引：24

作者：

BERGAMASCHI, M ^{[1
]}

CESERANI, R ^{[1
]}

PIERUCCI, L ^{[1
]}

POGLIANI, E ^{[1
]}

SPELTA, A ^{[1
]}

机构：

[1] UNIV MILAN,MED 1 CLIN,I-20133 MILAN,ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0031-6989(79)80090-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Indobufen inhibits platelet aggregation in vitro and after administration either by stomach tube or by intravenous injection in the guinea pig. It inhibits release of 14C serotonin by guinea pig platelets and PG and TXA2 synthesis in the isolated guinea pig lungs perfused with arachidonic acid. Although the drug slightly prolongs bleeding time, it does not affect the coagulation system. © 1979 The Italian Pharmacological Society.

引用

页码：279 / 294

页数：16

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