MONOCLONAL-ANTIBODIES AGAINST THE HUMAN LYMPHOCYTE DIFFERENTIATION ANTIGEN CD-76 BIND TO GANGLIOSIDES

被引：25

作者：

KNIEP, B

MUHLRADT, PF

DORKEN, B

MOLDENHAUER, G

VILELLA, R

SCHWARTZALBIEZ, R

机构：

[1] UNIV HEIDELBERG,DEPT INTERNAL MED,W-6900 HEIDELBERG,GERMANY

[2] GERMAN CANC RES CTR,INST IMMUNOL & GENET,W-6900 HEIDELBERG,GERMANY

[3] HOSP CLIN BARCELONA,SERV IMMUNOL,E-08036 BARCELONA,SPAIN

来源：

FEBS LETTERS | 1990年 / 261卷 / 02期

关键词：

2,6-Sialosyllactoneotetraosylceramide; B lymphocyte; Carbohydrate antigen; CD; 76; Immunostaining; Sialylation;

D O I：

10.1016/0014-5793(90)80588-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two monoclonal antibodies, HD 66 and CRIS-4, by which the new CD 76 B-cell-associated cluster was defined, bound to several gangliosides (sialic acid containing glycolipids) of different polarity. One of the gangliosides recognized by HD 66 could be identified as NeuAcα2-6Galβl-4GlcNAcβl-3Galβl-4Glc-βl-l'Cer. This antigen was enzymatically synthesized. Sialidase treatment of the ganglioside antigens abolished binding of HD 66 and CRIS-4. © 1990.

引用

页码：347 / 349

页数：3

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