PS-5, A NEW BETA-LACTAM ANTIBIOTIC .2. ANTI-MICROBIAL ACTIVITY

PS-5, a new β-lactam antibiotic1, has relatively potent antimicrobial activity against Gram-positive and Gram-negative bacteria, especially the Enterobacter groups, Serratia marcescens, the Proteus groups and Klebsiella pneumoniae. The activity of PS-5 against many β-lactamase-producing organisms is greater than that of cefoxitin or cefazolin. PS-5 has good therapeutic activity in mice infected with Staphylococcus aureus Smith or Enterobacter cloacae 45. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.