ENHANCED VASCULAR TONE IN THE RENAL VASCULATURE OF SPONTANEOUSLY HYPERTENSIVE RATS

被引:53
作者
GEBREMEDHIN, D [1 ]
FENOY, FJ [1 ]
HARDER, DR [1 ]
ROMAN, RJ [1 ]
机构
[1] MED COLL WISCONSIN, DEPT PHYSIOL, 8701 WATERTOWN PLANK RD, MILWAUKEE, WI 53226 USA
关键词
glomerular function; hemodynamics; kidney; microcirculation; renovascular hypertension;
D O I
10.1161/01.HYP.16.6.648
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The renal microvascular responses of Wistar-Kyoto and spontaneously hypertensive rats to changes in perfusion pressure were compared using a juxtamedullary nephron microvascular preparation perfused in vitro with a physiological salt solution containing 5% albumin. In the spontaneously hypertensive rats, the internal diameters of arcuate and interlobular arteries and the proximal and distal afferent arterioles averaged 307 ± 26, 52 ± 2, 24 ± 0.9, and 22 ± 1.2 μm, respectively, at 80 mm Hg. They were 18-35% smaller (p < 0.05) than the corresponding vessels measured in Wistar-Kyoto rats. In low calcium media, the arcuate and interlobular arteries and the proximal and distal afferent arterioles of spontaneously hypertensive rats exhibited a greater dilation than the vessels of Wistar-Kyoto rats. These observations suggest that the diameters of the preglomerular vasculature of the spontaneously hypertensive rats are reduced because of an elevated vascular tone rather than structural changes narrowing the lumen of these vessels. These results suggest that enhanced vascular tone in the preglomerular vasculature of juxtamedullary nephrons may contribute to the elevated renal medullary vascular resistance and resetting of the pressure-natriuretic relation previously observed in spontaneously hypertensive rats.
引用
收藏
页码:648 / 654
页数:7
相关论文
共 21 条
[1]   AUTO-REGULATION OF RENAL BLOOD-FLOW IN SPONTANEOUSLY HYPERTENSIVE RATS [J].
ARENDSHORST, WJ .
CIRCULATION RESEARCH, 1979, 44 (03) :344-349
[2]   ALTERATIONS IN RENAL VASCULAR-RESISTANCE AND REACTIVITY IN SPONTANEOUS HYPERTENSION OF RATS [J].
BERECEK, KH ;
SCHWERTSCHLAG, U ;
GROSS, F .
AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 238 (03) :H287-H293
[3]   MICROVASCULAR REACTIVITY OF INVITRO BLOOD PERFUSED JUXTAMEDULLARY NEPHRONS FROM RATS [J].
CASELLAS, D ;
CARMINES, PK ;
NAVAR, LG .
KIDNEY INTERNATIONAL, 1985, 28 (05) :752-759
[4]   INVITRO PERFUSION OF JUXTAMEDULLARY NEPHRONS IN RATS [J].
CASELLAS, D ;
NAVAR, LG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (03) :F349-F358
[5]   RENAL VASCULAR REACTIVITY IN THE YOUNG SPONTANEOUSLY HYPERTENSIVE RAT [J].
COLLIS, MG ;
DEMEY, C ;
VANHOUTTE, PM .
HYPERTENSION, 1980, 2 (01) :45-52
[6]   PRIMARY ROLE OF RENAL HOMOGRAFTS IN SETTING CHRONIC BLOOD-PRESSURE LEVELS IN RATS [J].
DAHL, LK ;
HEINE, M .
CIRCULATION RESEARCH, 1975, 36 (06) :692-696
[7]   ENHANCED TUBULOGLOMERULAR FEEDBACK ACTIVITY IN RATS DEVELOPING SPONTANEOUS HYPERTENSION [J].
DILLEY, JR ;
ARENDSHORST, WJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (04) :F672-F679
[8]  
EVAN AP, 1981, HYPERTENSION, V3, P154
[9]   STRUCTURAL RESETTING OF RENAL VASCULAR BED IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) [J].
FOLKOW, B ;
GOTHBERG, G ;
LUNDIN, S ;
RICKSTEN, SE .
ACTA PHYSIOLOGICA SCANDINAVICA, 1977, 100 (02) :270-272
[10]  
GLANTZ SA, 1987, PRIMER BIOSTATISTICS, P30