SEROLOGICALLY DEFINED LINEAR EPITOPES IN THE E2 ENVELOPE GLYCOPROTEIN OF SEMLIKI FOREST VIRUS

被引：2

作者：

ARIEL, N ^{[1
]}

LEHRER, S ^{[1
]}

ELHANATY, E ^{[1
]}

SABO, T ^{[1
]}

BRODT, P ^{[1
]}

LACHMI, B ^{[1
]}

KATZ, D ^{[1
]}

LEVIN, R ^{[1
]}

GROSFELD, H ^{[1
]}

VELAN, B ^{[1
]}

SHAFFERMAN, A ^{[1
]}

机构：

[1] ISRAEL INST BIOL RES,DEPT VIROL,IL-70450 NESS ZIONA,ISRAEL

来源：

ARCHIVES OF VIROLOGY | 1990年 / 113卷 / 1-2期

关键词：

D O I：

10.1007/BF01318358

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A set of 41 overlapping peptides, representing the complete sequence of SFV-E2 protein were synthesized and analyzed in the ELISA test against murine anti-SFV sera. No single peptide was recognized by all antisera. Eight peptides were found to be highly reactive with hyperimmune anti-SFV sera. Six out of the eight peptide sequences coincide with the most hydrophilic regions of SFV-E2. Out of these, four peptides (amino acid positions 16-35, 61-80, 166-185, 286-305) that contain the least number of alphavirus conserved residues were selected. This panel constitutes the minimal number of peptides necessary and sufficient for specific recognition of hyperimmune mouse anti-SFV sera. © 1990 Springer-Verlag.

引用

页码：99 / 106

页数：8

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