LINKAGE MAPPING OF HIGHLY INFORMATIVE DNA POLYMORPHISMS WITHIN THE HUMAN INTERFERON-ALPHA RECEPTOR GENE ON CHROMOSOME-21

被引：35

作者：

MCINNIS, MG

LUTFALLA, G

SLAUGENHAUPT, S

PETERSEN, MB

UZE, G

CHAKRAVARTI, A

ANTONARAKIS, SE

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[4] CNRS,VIRAL ONCOL LAB,F-94800 VILLEJUIF,FRANCE

[5] UNIV PITTSBURGH,DEPT PSYCHIAT,PITTSBURGH,PA 15261

[6] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261

来源：

GENOMICS | 1991年 / 11卷 / 03期

关键词：

D O I：

10.1016/0888-7543(91)90064-L

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21. © 1991.

引用

页码：573 / 576

页数：4

共 21 条

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